HORDB

ID: hor006190
Uniprot ID: P31241
Protein name: Molluscan insulin-related peptide 5 A chain
Gene name: NA
Organism: Lymnaea stagnalis (Great pond snail) (Helix stagnalis)
Family: Insulin family
Source: Animal
Expression: Expressed in the cerebral light-green cells which are giant neuroendocrines cells involved in the control of growth.
Disease: NA
Comments: NA
Taxonomy: Lymnaea (genus), Lymnaeidae (family), Lymnaeoidea (superfamily), Hygrophila , Panpulmonata , Euthyneura , Heterobranchia (subclass), Gastropoda (class), Mollusca (phylum), Lophotrochozoa , Spiralia , Protostomia , Bilateria , Eumetazoa , Metazoa (kingdom), Opisthokonta , Eukaryota (superkingdom),cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0007165 signal transduction
GO CC: GO:0005576 extracellular region; GO:0030133 transport vesicle; GO:0031410 cytoplasmic vesicle

Sequence: QRTTNLVCECCYNVCTVDVFYEYCY
Length: 25(114-138)
Propeptide: MAGVRLVFTKAFMVTVLLTLLLNIGVKPAEGQFSACSFSSRPHPRGICGSDLADLRAFICSRRNQPAMVKRDAETGWLLPETMVKRNAQTDLDDPLRNIKLSSESALTYLTKRQRTTNLVCECCYNVCTVDVFYEYCY
Signal peptide: MAGVRLVFTKAFMVTVLLTLLLNIGVKPAEG
Modification: T1 Pyrrolidone carboxylic acid
Glycosylation: NA
Mutagenesis: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor006190_AF2.pdb

hor006190_ESM.pdb

Mass:	346071	Formula:	C131H191N31O42S5
Absent amino acids:	AGHIKMPSW	Common amino acids:	C
pI:	3.93	Basic residues:	1
Polar residues:	14	Hydrophobic residues:	6
Hydrophobicity:	12.4	Boman Index:	-3389
Half-Life:	0.8 hour	Half-Life Yeast:	10 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	62
Instability Index:	3821.6	Extinction Coefficient cystines:	6210
Absorbance 280nm:	258.75

PubMed ID: 1323019
Title: Characterization of a cDNA clone encoding molluscan insulin-related peptide V of Lymnaea stagnalis.